Technical Specialist Manager - Process Analytical Technologies PAT - astrazeneca

Job Title: Technical Specialist Manager – Process Analytical Technologies (PAT)

Career Level: E

Introduction to role:

Are you ready to design real-time analytics and control that turn sophisticated biologics and conjugates into reliable, scalable manufacturing outcomes for patients? In this role, you will architect and lead Process Analytical Technology (PAT) across our ADC manufacturing campus—spanning incoming material testing, small- and large-molecule production, conjugation, sterile filling, and lyophilization—to drive quality, speed, and consistency at scale.

You will set the strategy and deliver hands-on solutions that enable advanced process control, self-regulating loops, digital twins & and data-driven decision making. Working closely with Manufacturing, Engineering, Digital, Automation and QA teams, you will accelerate our move toward autonomous manufacturing and continuous process verification while meeting GMP and regulatory expectations. Could you turn raw signals into actionable insight and closed-loop control that boosts yield and robustness? Do you want your work to directly increase the reliability and availability of medicines for patients, while supporting bold sustainability ambitions across our network?

Accountabilities:

PAT Strategy and Roadmap: Define and implement a site-wide PAT strategy aligned to manufacturing scale-up, digitalisation, and operational excellence objectives, with clear value and risk profiles.

Technology Selection and Lifecycle: Identify, evaluate, and deploy spectroscopy, sensors, soft sensors, and real-time analytics; own lifecycle management from proof-of-concept to validated, GMP-grade performance.

Site Domain Expertise: Serve as the SME for PAT, multivariate data analysis, Chemometrics and advanced process control to guide critical decisions and unlock deep process understanding.

Modeling and Advanced Analytics: Build and maintain process models, predictive analytics, and digital twins that translate data into stabilised processes, higher yields, and faster investigations.

Closed-Loop and Self-Regulating Control: Design and implement advanced strategies that increase capability, reduce variability, and improve efficiency.

Systems Integration: Integrate PAT platforms with DCS, SCADA & Manufacturing Execution Systems (MES), and data architectures in partnership with Automation, Digital, Process Engineering, and QA teams.

Governance and Compliance: Establish standards for data integrity, model lifecycle management, validation, and performance monitoring to meet GMP & regulatory requirements.

Capital and Deployment Leadership: Lead PAT-related capital projects and multi-asset deployments, ensuring robust user requirements, vendor selection, commissioning, and qualification.