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Research Associate - Precision Nanopipette Delivery for Mitochondrial Genome Engineering - Imperial College London
Software Engineer
Conduct cutting‑edge research on programmable nanopipette delivery systems for mitochondrial genome editing, combining nanofabrication, live‑cell imaging, and CRISPR‑based molecular techniques.
About the role
Key Responsibilities
- Design, fabricate, and optimise nanometer‑scale pipettes for targeted delivery of nucleic acids into mitochondria.
- Develop and implement live‑cell fluorescence microscopy protocols to monitor delivery efficiency and mitochondrial function.
- Integrate CRISPR‑based genome editing tools with the nanodelivery platform to achieve precise mitochondrial DNA modifications.
- Analyse experimental data using Python and MATLAB, generating quantitative metrics and visualisations.
- Collaborate with interdisciplinary partners across Imperial College London, University of Bristol and University of Glasgow, contributing to joint publications and grant reports.
Requirements
- PhD or equivalent experience in nanotechnology, molecular biology, or a related field.
- Proven hands‑on experience with nanofabrication techniques (e.g., focused ion beam, electron beam lithography).
- Strong background in fluorescence microscopy and live‑cell imaging.
- Experience with CRISPR‑based genome editing, preferably targeting mitochondrial DNA.
- Proficiency in Python or MATLAB for data analysis and scripting.