Principal Clinical Scientist

Principal Clinical Scientist, ECD

About the Role

We are seeking a Principal Clinical Scientist to lead execution of key components of clinical development for our early cancer detection (ECD) program. This role is central to driving study design, clinical data review, and scientific insights across multiple studies.

You will serve as a clinical science lead within cross-functional teams – partnering with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory to advance study execution and shape clinical strategy. This is a high-impact role for someone who can operate independently, manage complexity across studies, and influence decision-making at the study and program level.

PRIMARY RESPONSIBILITIES

Lead Clinical Development & Study Design

Lead substantial aspects of ECD clinical studies or multiple studies

Drive study design, including objectives, endpoints, eligibility criteria, and schedules of assessments

Author and review protocols, ICFs, CRFs, and study documents

Contribute meaningfully to clinical development strategy and study-level decision-making

Contribute to process improvements and development of best practices

Drive Data Review & Strategic Insight

Lead medical and clinical data review to ensure data quality and integrity

Analyze complex datasets to identify trends, risks, and opportunities

Translate data into actionable insights that inform study and program decisions

Partner with safety and medical teams on signal detection and escalation

Lead Cross-Functional Execution

Lead cross-functional study teams and coordinate execution across functions

Collaborate with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory

Influence decisions and align stakeholders across competing priorities

Represent Clinical Science in internal and external forums (e.g., investigators, KOLs)

Drive Study Performance & Program Value

Oversee enrollment, site performance, and key study metrics across studies

Identify risks and proactively adjust study-level strategies

Prioritize activities across studies to ensure quality, timelines, and program impact

Contribute to forecasting, planning, and milestone delivery

Advance Scientific Communication

Lead development of abstracts, presentations, and manuscripts

Translate clinical and statistical results into clear scientific narratives

Support internal decision-making and external evidence generation

Required Qualifications

Advanced degree (PhD, PharmD, MD, or equivalent; MS/RN with experience considered)

8–12 years of experience in clinical research, clinical science, or related field

Strong experience leading clinical studies and contributing to study design

Experience with clinical data review and interpretation

Preferred Qua