About Axle
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Benefits We Offer:
- 100% Medical, Dental & Vision Coverage for Employees
- Paid Time Off and Paid Holidays
- 401K match up to 5%
- Educational Benefits for Career Growth
- Employee Referral Bonus
- Flexible Spending Accounts:
- Healthcare (FSA)
- Parking Reimbursement Account (PRK)
- Dependent Care Assistant Program (DCAP)
- Transportation Reimbursement Account (TRN)
About the Role
Axle is seeking a visionary and operationally astute Associate Director of Artificial Intelligence, Modeling, and Data to lead our charge at the frontier of biomedical innovation. In this pivotal leadership role, you will architect the future of AI-driven discovery, bridging the gap between advanced computational science and life-saving clinical research.
Sitting at the nexus of our Data Science and Biomedical Research divisions, you will oversee the strategic development and deployment of high-performance AI/ML solutions that empower federal health agencies, including the National Institutes of Health (NIH) and the National Center for Advancing Translational Sciences (NCATS). You will be the technical conscience and strategic driver for a diverse portfolio of projects, ranging from the optimization of our open-source Polus platform to the implementation of Generative AI pipelines for drug discovery and high-dimensional data analysis.
This is not merely a management role; it is a mission-critical position for a leader who is passionate about the "public good" of science. You will galvanize interdisciplinary teams of PhD scientists, machine learning engineers, and software architects to solve complex health challenges, such as pandemic preparedness and rare disease treatment. As an Associate Director, you will combine deep technical expertise with executive presence, serving as a trusted advisor to government stakeholders and a key architect of Axle’s long-term growth in the federal health IT sector.
Core Responsibilities:
1. Strategic Leadership of the AI/ML Roadmap
- Visionary Architecture: Architect and execute a comprehensive AI/ML strategy that aligns Axle’s technical capabilities with the NIH Strategic Plan for Data Science (2025–2030). You will define the long-term vision for integrating Generative AI, Large Language Models (LLMs), and Agentic Workflows into federal research environments, moving beyond static analysis to active, AI-assisted discovery.
- Platform Evolution (Polus): Spearhead the evolution of the Polus platform, transitioning it from a robust image analysis tool into a fully integrated, multi-modal research ecosystem. You will oversee the roadmap for new feature development, ensuring scalability, security, and interoperability across cloud environments (AWS/GCP/Azure) using containerized architectures (Docker/Kubernetes).
- AI Governance & Compliance: Establish and enforce rigorous AI Governance frameworks. You will operationalize the NIST AI Risk Management Framework (RMF) across all projects to ensure fairness, interpretability, and compliance with federal ethical standards. You will lead "Gap Analysis" and "Risk Management" exercises to ensure all AI deployments are trustworthy and transparent.
2. Oversight of Complex Modeling & High-Dimensional Data Pipelines
- Petabyte-Scale Engineering: Direct the design and implementation of high-throughput data pipelines capable of ingesting and analyzing petabyte-scale datasets (genomics, proteomics, EHR). You will ensure these systems adhere to FAIR data principles (Findable, Accessible, Interoperable, Reusable), facilitating seamless data sharing across NIH institutes and global research centers.
- Translational Science De-risking: Oversee the development of predictive models for translational science, focusing on "de-risking" drug discovery and clinical trial design. This involves guiding technical teams in the application of deep learning techniques to identify molecular targets, predict therapeutic outcomes, and simulate clinical scenarios (Digital Twins).
- Operational Excellence (MLOps): Optimize MLOps and DevSecOps processes to ensure the rapid, secure deployment of models from prototype to production. You will champion a culture of "automation first," reducing time-to-insight for researchers by streamlining the transition from Jupyter notebooks to containerized, cloud-native services.
3. Business Development & Federal Growth (Capture Support)
- Lead Solution Architect: Partner with the Growth and Capture teams to drive new business acquisition. You will serve as the Lead Solution Architect for major proposal efforts ($50M+), authoring technical volumes, developing win themes, and creating compelling solution graphics that demonstrate Axle’s technical differentiation.
- Proposal Authorship: Personally write key sections of technical proposals, including the "Technical Approach," "Staffing Plan," and "Risk Mitigation" volumes. You will translate complex agency requirements into winning narratives that score highly with federal evaluators.
- Client Liaison: Galvanize relationships with key federal stakeholders (Project Officers, CIOs, Lab Chiefs). You will act as the primary technical liaison, translating complex agency requirements into deliverable technical solutions and presenting these visions in competitive "Black Hat" sessions and oral presentations.
4. Mentorship of Data Scientists & Engineers
- Interdisciplinary Team Building: Cultivate a high-performance, interdisciplinary team culture. You will manage and mentor a diverse group of data scientists, bioinformaticians, and software engineers, fostering an environment of psychological safety where "expert" scientific knowledge seamlessly integrates with "agile" engineering practices.
- Continuous Learning: Drive continuous learning and upskilling initiatives. You will establish internal "Communities of Practice" for AI and Data Science, ensuring that Axle’s workforce remains at the bleeding edge of technologies like Graph Neural Networks and Federated Learning.
- Democratization of AI: Democratize access to AI tools within the client environment. You will lead efforts to create "low-code/no-code" interfaces and training programs that empower non-technical NIH researchers to utilize advanced analytics independently.
Required Qualifications:
To effectively lead in this high-stakes environment, candidates must possess a rare combination of advanced academic training and battle-tested industry experience.
Education:
- Ph.D. in Computer Science, Bioinformatics, Computational Biology, Data Science, or a related quantitative discipline is highly preferred to ensure peer-level credibility with NIH scientists.
- Alternatively, a Master’s degree in one of the above fields with exceptional, demonstrated leadership experience in a federal or research-intensive setting will be considered.
Experience:
- 8–10+ years of progressive experience